On temporal homogenization in the numerical simulation of atherosclerotic plaque growth

A temporal homogenization approach for the numerical simulation of atherosclerotic plaque growth is extended to fully coupled fluid-structure interaction (FSI) simulations. The results indicate that two-scale yields significantly different compared a simple heuristic averaging, where only stationary long-scale FSI problems are solved, confirming importance incorporating stress variations on small time-scales. In approach, periodic fine-scale problem, which with respect heart beat, has be solved each time step. Even if no exact initial conditions available, periodicity can achieved within 2–3 beats by time-stepping.